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10.1172/JCI120412 J

We understand why this question comes up, as there's a lot of chatter online and in various wellness circles

Important to note, both PLP and 5-methyltetrahydrofolate require riboflavin in their biosynthesis using the active forms of riboflavin, FMN, and FAD, respectively (89) (Figure 4)

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[] Variations in genetic background, baseline diets, and study design may explain inconsistent outcomes, and while omega-3s offer a promising preventive strategy, overgeneralization should be avoided without further large-scale, controlled trials